Changes in fibrinolytic activity of blood after prostatectomy.

After prostatectomy, hypofibrinogenemia and bleeding were reported earlier. The objective of present study is to find out, of blood, after prostatectomy. Blood samples of patients posted for operations were studied by following tests before and after operation along with controls. 1. Euglobulin lysis time. 2. Plasminogen assay. 3. Fibrinogen estimation. The results showed clearly that there is decrease in euglobulin lysis time indicating increased plasminogen activator level, increased plasminogen level and decreased fibrinogen level after the operation. This suggests that there is significant increase in fibrinolytic activity of blood after prostatectomy leading to hypofibrinogenemia and clotting defects.